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T-01: "PEP" – Personalized Effect-Controlled Pharmacotherapy

Development of a miniaturized infusion pump system for personalized , patient-specific , effect-controlled pharmacotherapy
Projekttyp: 

Nowadays, treatment with medicines can only be handled within strict limits according to the needs of the individual patient and adapted to the situation in hand. The continuous and variable intake of liquid medicines through a new, miniaturized infusion pump system is designed to enable personalized, individual, effect-controlled treatment with drugs. This could lead to substantial progress, especially in post-operative and oncologic pain management. The aim is to develop algorithms that take into account the degree of therapeutic success as assessed by the patient, as well as the monitoring of the side-effects of analgesics by means of coupling with sensors for appropriate respiratory and circulatory correlates. Remote monitoring systems are also being evaluated in this context, so that they can be integrated into subsequent developments of the basic product.

Planning is divided into two closely meshed focal points of the project:

  1. Concepts will be drawn up and assessed in terms of their strengths and weaknesses in a basic technical development for a miniaturized infusion pump system. Prototypes will then be developed, verified in laboratory tests and clinically validated.
  2. At the same time, the algorithms will be worked out and evaluated in scientific work packages. Through a number of development stages, they should then lead to a personalized effect-controlled infusion system.

Project Duration

01.07.2010 - 30.04.2015

Project Partners

  • Fresenius Kabi AG
  • Universitätsklinikum Erlangen

 

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