A-07: Selective surface modification of intraocular lenses by means of ultrashort-pulsed laser radiation to reduce reflections
At the heart of the project is the idea of developing an IOL that can safely prevent the occurrence of negative dysphotopsia (ND).
ND is a post-surgery complication that occurs in up to 15% of patients following implantation of modern foldable lenses, e.g. in the treatment of cataracts. Patients with this complication complain of an irritating, blinder-like restriction of the visual field which is most likely caused by shadows. These shadows are attributed to edge glare phenomena. Affected patients typically suffer from a greatly diminished quality of vision and quite frequently request explantation of the IOL and restoration of the condition before surgery. This highlights the importance of developing an IOL that can safely prevent the occurrence of this phenomenon when it comes to improving the quality of treatment and reducing follow-up costs.
Brief project description
ND occurs only with modern IOLs that have comparably sharp optic edges. It was not observed with round-edged IOLs. The design of the optic edge thus plays an important role. Because round optic edges have the major disadvantage of being associated with the occurrence of posterior capsular opacification (PCO), this edge shape is not an option.
The project consists of two subprojects, one of which (HumanOptics) deals with the numeric and experimental simulation for reproducing ND. This will provide an understanding of the causes of ND. On the basis of these results, novel edge designs will be conceived that prevent the occurrence of both ND and PCO. At the end of this subproject, the effect of these novel edge designs with regard to preventing ND will be verified through experiments. This involves producing prototypes and testing them in experimental setups for simulating ND.
The second subproject (LPT) deals with the selective modification of surfaces by means of ultrashort-pulsed laser radiation. For this, a suitable experimental setup will be provided and the process limits of the modification of IOL edges will be systematically examined using ultrashort-pulsed laser radiation. Subsequent to this, prototypes with differently modified optic edges will be produced which will then be experimentally verified within the HumanOptics subproject for their effect with regard to preventing ND.
The project will conclude with tests examining the effect of the optic edge modification by ultrashort-pulsed laser radiation on the general biocompatibility properties.
01.01.2013 - 31.12.2014
- HumanOptics AG
- Friedrich-Alexander-University Erlangen-Nuremberg (FAU)
Dr. Arthur Meßner
+49-9131-50 665 77