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A-06: Semi-synthetic corneal substrate for reconstructing and regenerating the surface of the eye

Development and experimental and clinical testing of semisynthetic corneal substrate for reconstruction and regeneration of the ocular surface
Projekttyp: 

SEMI-SYNTHETIC CORNEAL SUBSTRATE FOR RECONSTRUCTING AND REGENERATING THE SURFACE OF THE EYE 

There is a large number of patients suffering from corneal diseases that lead to superficial wound healing impairment with opacity of the corneal epithelium and/or corneal stroma. There is a high demand for materials to cover such corneal surface defects. The objective of this experimental project is to develop various semi-synthetic biomatrices based on collagen for the individual treatment of various types of eye surface defects, and to conduct subsequent experimental and clinical trials.

Development will include the production of variants of a biomatrix made of equine collagen. During the trials, these biomatrices will be examined in terms of strength, transparency, swelling properties, bio-compatibility with respect to the induction of inflammation reactions and blood vessel growth, influence on migration of the corneal epithelium, invasion of keratinocytes and nerves, as well as resorption and degradation. The examinations will first be conducted in corneal epithelium cell cultures, in which the biomatrices serve as growth substrates. These will be followed by animal experiments in which the biomatrices will be implanted in the corneas of rabbits. An observation study on humans should then supply information on the requirements placed on the biomatrices in terms of individual illnesses.

Project Duration

01.10.2010 - 31.03.2013

Project Partners

  • RESORBA Wundversorgung GmbH & Co. KG
  • University Clinic Erlangen

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