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BD-20: Haemodynamic simulation and personalised treatment for neurovascular disorders

Tapping into a new dimension of haemodynamic simulation directly in an interventional environment

Project aims

The overarching aim of the project is to tap into a new dimension of haemodynamic simulation directly in an interventional environment and provide personalised treatment for cerebrovascular disorders. The project focus, particularly the creation of an efficient, realistic, temporal and spatial simulation of haemodynamic data and the resulting treatment optimisation in terms of individualised medicine, is in accordance with the objectives of the top cluster, particularly the interdisciplinary, workflow-based development of new imaging and image-processing techniques. A sustainable improvement in personalised, implant-based forms of treatment for cerebral vascular disorders leads to a quantitatively measurable increase in the effectiveness and efficiency of our healthcare system. In accordance with the funding policy objectives of the top cluster, clinical and industrial research expertise and activity are closely linked both spatially and in terms of content right from the beginning and bundled together at a high level.

Brief description of the project

In industrialised countries, neurovascular disorders such as intracranial aneurisms and stenosis represent a frequent cause of stroke and death, often associated with lasting disability and overall a significant cost factor. It is true that interventional methods and new developments in imaging have significantly expanded the treatment options and can improve the treatment outcome. However, the potential to boost the efficiency of treatment for cerebral vascular disorders, particularly in terms of personalised treatment, and thus increase the quality of treatment while also reducing costs overall has by no means been exhausted. Haemodynamic effects play a major role in the development and also long-term treatment success of cerebral aneurisms and stenosis. It would thus be of great clinical benefit to have the option of fast, automatic simulation of a specific patient’s haemodynamic changes directly in the periinterventional environment. The overarching aim of this interdisciplinary project is to tap into a new dimension of temporal and spatial haemodynamic simulation and provide personalised treatment for cerebrovascular disorders. The aim is to acquire optimised high-quality data sets, initially based on experimental data, and develop automated post-processing techniques. Based on high-resolution angiography data, an efficient algorithm for the fast, largely automated spatial and temporal simulation of haemodynamic data should also be developed at the same time. In a second section of the project, these algorithms should be implemented in an interventional environment, embedded in the workflow and a variety of haemodynamic statistics evaluated using clinical reference values. The long-term objective here is the implant-based optimisation of the treatment chain in terms of personalised treatment. Overall, it is a highly innovative project with great medical and economic potential that, if successful, is sustainably anchored in the current interventional treatment of cerebral vascular disorders in terms of personalised treatment. Specifically, customised endovascular treatment could significantly improve treatment outcomes, especially over the long term, and thus make a direct and indirect contribution to significantly reducing costs in the healthcare system.

Project duration

01.10.2013 - 30.04.2015

Contact

Prof. Dr. Arnd Dörfler
Neuroradiology Department
University Hospital Erlangen
Friedrich-Alexander-Universität Erlangen-Nürnberg

Schwabachanlage 6
91054 Erlangen

arnd.doerfler@uk-erlangen.de
Tel.: +49-9131-8534326

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